Testing mutual intelligibility between closely related languages in an oral society

This paper describes a new methodology for testing intelligibility across closely related languages and dialects in a traditional oral society in Vanuatu. There are many reasons why it could be useful to establish how well speakers of related varieties can understand one another: such knowledge is relevant to language planning and policy making, and it can shed light on the dynamics of language contact. However, conventional approaches to intelligibility testing, such as ‘recorded text testing’ (Hickerton et al. 1952; Pierce 1952; Voegelin & Harris 1951), are time consuming to score, and difficult to implement consistently. In Europe, fast and efficient intelligibility testing has been successfully carried out across closely related varieties (cf. Vanhove 2014; Gooskens forthcoming; Schüppert & Gooskens 2011a, 2011b, inter alia). However, these methods assume that test subjects are literate and computer-savvy. The methodology discussed in the present paper adapts European methods to conventional ‘fieldwork’ conditions. In Vanuatu we piloted a picture task and a translation task. Although some words had to be removed from the final analysis, the experiment was successful overall and we anticipate that this method can be fruitfully applied in other oral language communities.National Foreign Language Resource Cente

Human Urinary Bladder Strip Relaxation by the β-Adrenoceptor Agonist Isoprenaline: Methodological Considerations and Effects of Gender and Age

The present study was primarily designed to explore various methodological aspects related to organ bath experiments evaluating human detrusor relaxation by the β-adrenoceptor agonist isoprenaline. Data are based upon a series of 30 consecutive patients, and this cohort was also used to explore possible effects of gender and age. KCl-induced contraction was related to strip length but not weight or cross-sectional area, indicating that the former is most suitable for data normalization. Storage of detrusor strips in cold buffer for up to 2 days did not affect contractile responses to KCl or efficacy of isoprenaline to cause relaxation but significantly affected the isoprenaline potency. No such alterations were observed with up to 1 day of cold storage. The type (KCl vs. passive tension) or strength of contractile stimulus had only minor effects on isoprenaline responses although these differences reached statistical significance in some cases. Similarly, gender and age had only minor if any effects on KCl-induced contraction or isoprenaline-induced relaxation, but the current data are too limited for robust conclusions. In summary we have evaluated experimental conditions for the testing of human detrusor strip contraction and relaxation which should be useful for future larger studies

Study protocol for a multi-center RCT testing a group-based parenting intervention tailored to mothers with borderline personality disorder against a waiting control group (ProChild*-SP1)

Background/aims Borderline personality disorder (BPD) is a severe mental disorder characterized by an unstable sense of self, intense and rapidly changing affect, as well as impulsive and self-destructive behaviors. Interpersonal relationships of individuals with BPD are characterized by marked instability, a lack of dependability, and quick changes between love and hate. For children of individuals with BPD, this can lead to permanent stress and attachment insecurity and an increased risk of adverse physical and mental health development. To reduce dysfunctional parenting and improve positive parenting, and in turn, to promote healthy child development, a group intervention for mothers with BPD was developed. This study aims to evaluate this first disorder-specific parenting intervention for BPD in a randomized controlled trial. Method In a parallel-group, two-arm, randomized controlled trial, an initial N = 178 mothers diagnosed with BPD and their children aged 6 months to 6 years are assigned to either the parenting intervention or a waiting control group. If taking place, participants of both groups continue their regular treatment for BPD diagnosis (e.g., individual therapy, medication). The primary outcomes are changes in parenting from baseline (day 0) to post intervention (week 12) and follow-up (6 months after group intervention; month 9). The waiting control group can attend the group intervention at the end of all assessments. Participants allocated to the intervention group are expected to show improvement in their parenting and a reduction in child abuse potential. Maternal emotion regulation and mental distress are analyzed as secondary outcomes. Discussion Mothers with BPD may need tailored help when reporting difficulties raising their children. The first disorder-specific parenting intervention has been developed to close this gap. ProChild is part of a large government-supported consortium, which aims to investigate different aspects of abuse and maltreatment in childhood and adolescence

A Follow-up Analysis of Listener (Mis)comprehension across Language Varieties in Pentecost, Vanuatu

Intelligibility testing in Vanuatu in 2015 investigated how well speakers of three closely related varieties could understand each other. But the research also generated questions about (1) anomalous results; (2) which linguistic factors influenced comprehension; and (3) the relative intelligibility of varieties. This paper interrogates these questions and finds that, first, while most anomalous results are difficult to account for, others are easily explained; the insights gained will help to refine the design of future intelligibility tests. Second, some variables appear to be more important than others in terms of the degree to which they impede intelligibility. Third, test participants' higher comprehension of a relatively distantly related variety over a more closely related variety leads to explanations that draw on both linguistic and social factors. The insights gained in this study contribute to existing research on the same topic in European languages and establish a starting point for similar research on Pacific languages

Inverse folding for antibody sequence design using deep learning

We consider the problem of antibody sequence design given 3D structural information. Building on previous work, we propose a fine-tuned inverse folding model that is specifically optimised for antibody structures and outperforms generic protein models on sequence recovery and structure robustness when applied on antibodies, with notable improvement on the hypervariable CDR-H3 loop. We study the canonical conformations of complementarity-determining regions and find improved encoding of these loops into known clusters. Finally, we consider the applications of our model to drug discovery and binder design and evaluate the quality of proposed sequences using physics-based methods.Comment: 2023 ICML Workshop on Computational Biology, model weights available at https://zenodo.org/record/816469

Mein Traum von Bibliothek

Unter dem Titel „Mein Traum von Bibliothek“ wird demnächst an der Universitätsbibliothek Leipzig eine Vortragsreihe für Bibliothekare starten. Thema ist der von uns allen erlebte rasante Wandel in der Mediennutzung durch digitale Technik. Die Aufgaben der Bibliothek ändern sich, die Tätigkeiten der Bibliothekare ändern sich, die Funktionen der Bibliotheksräume ändern sich. Das hat Konsequenzen für alle wissenschaftlichen Bibliotheken, ins besondere für ein komplexes System wie das der UB Leipzig mit derzeit noch 19 Zweigbibliotheken. Welche Räume hat eine Bibliothek, wenn sowohl die Informationen wie die Wege dahin digital formatiert sind? Welcher Service sollte geboten werden

Fostering exploration and exploitation behavior in management teams to enhance organizational performance: the LearnOvation leadership development program

This article is published under the Creative Commons Attribution (CC BY 4.0) licence. Anyone may reproduce, distribute, translate and create derivative works of this article (for both commercial and non-commercial purposes), subject to full attribution to the original publication and authors. The full terms of this licence may be seen at http:// creativecommons.org/licences/by/4.0/legalcodePurpose – The purpose of this paper is to assess the impact and effectiveness of the LearnOvation leadership development program in the welfare services sector in Sweden. Design/methodology/approach – LearnOvation was based on ambidexterity theory for the program content and the research study design. A mixed-method design was applied, using questionnaires among staff (n 5 523) and written evaluations with the management teams (n 5 60). Findings – Quantitative analysis of the questionnaires indicated little change in managers’ and staffs’ innovation behaviors, though employee exploration behaviors were strongly and positively correlated with their innovation behaviors. Qualitative leader-written evaluations reported increased understanding of innovation management and the use of exploration and exploitation activities to involve staff in the implementation of creative ideas within the organization. Practical implications – The authors argue that innovating is about creating a fertile ground for exploration and exploitation processes of learning that support staff’s willingness to meet goals, as well as their capability to explore new ideas and experiment in new ways of working. Leadership development activities that engage the entire management team can build the necessary capacity and power to lead innovation processes in highly structured welfare services and free the employees’ innovativeness, potentially leading to improved services and employee satisfaction. Originality/value – With the goal of enhancing the innovation capacity in daily practice, this study adds to the scarcity of research in welfare services on how to actually support management’s work on leading successful implementation of creative ideas.publishedVersio

Content validity of the Work Rehabilitation Questionnaire (WORQ) for persons with spinal cord injury:A mixed methods study

STUDY DESIGN: Mixed methods. OBJECTIVES: The aim of our study was to investigate the content validity of the Work Rehabilitation Questionnaire (WORQ) for use in persons with post-acute and chronic spinal cord injury (SCI). SETTING: A university-based Rehabilitation Center in The Netherlands. METHODS: Contents of the WORQ, brief ICF core sets for SCI for post-acute care and for chronic situation were compared with semi-guided interviews with persons with SCI and controlled for relevance by SCI rehabilitation professionals in two group meetings. RESULTS: Fourteen interviews with persons with SCI were performed. Two group meetings with 8 and 9 SCI rehabilitation professionals were held. Thirty seven of the 46 ICF categories (80%) of the WORQ were confirmed by both sources: mentioned in interviews with persons with SCI and considered important by the SCI professionals. The remaining 9 categories (20%) were confirmed by either the persons with SCI or the SCI professionals. Fourteen ICF categories that are part of the brief ICF core set for SCI for acute care and/or chronic situation, however are not part of the WORQ, have revealed importance by persons with SCI and SCI professionals. CONCLUSION: Our study confirms that most categories of the WORQ are important to consider for VR in persons with SCI, however, there are ICF categories that are absent in the WORQ and deemed relevant for use in VR in persons with SCI. Consequently, the content validity of the WORQ without additional items is insufficient for persons with SCI